1400s
An indigenous group referred to as the "Monongahela tradition" are still living in Washington County between 1000 A.D and the 1630's. Source. Also visit Indigenous people of Pennsylvania.
1453-May 29th The capital of the Eastern Roman Empire, Constantinople was conquered by the Ottoman Army, under the command Ottoman Sultan Mehmed II.
1473-Sistine Chapel construction begins.
1485-First English outbreak of "sweating sickness" kills thousands: repeated in 1506, 1517,1528, and after to claim several million.
1495-Epidemic of syphilis sweeps Europe.
1487-Leonardo da Vinci's famous Vitruvian Man, a drawing created circa 1487, with the 7 chakras or energy centers indicated.
1492-Christopher Columbus reaches the New World.
1503-1519-Mona Lisa painted by Italian artist Leonardo da Vinci. Painting most likely of Lisa del Giocondo.
1507-The first outbreak of smallpox in the New World spreads to Mexico by 1520. Several million die.
1528-Typhus epidemic in Italy claiming a few hundred thousand lives.
1554-De Materia Medica, book 6, published in Lugdunum.
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